Deep-brain stimulating (DBS) electrodes used to treat movement disorders such as Parkinson’s disease require neurosurgery in order to implant electrodes and batteries into patients. Transcranial magnetic stimulation (TMS) used to treat drug-resistant depression and other disorders do not require surgery, but have a low spatial resolution of approximately one centimeter and cannot stimulate deep brain circuits where many diseased circuits reside.
To overcome the above limitations, my laboratory has engineered a novel technology which implements transcranial pulsed ultrasound to remotely and directly stimulate brain circuits without requiring surgery. Further, we have shown this ultrasonic neuromodulation approach confers a spatial resolution approximately five times greater than TMS and can exert its effects upon subcortical brain circuits deep within the brain.

A portion of our initial work has been supported by the U.S. Army Research, Development and Engineering Command (RDECOM) Army Research Laboratory (ARL) where we have been working to develop methods for encoding sensory data onto the cortex using pulsed ultrasound...